About William DePippo
Real estate executive with 30 years of experience leading complex, multi-regional development projects for publicly traded Fortune 500 companies.
SVP of Development & Construction
Deep expertise in life sciences, commercial development, strategic repositioning, infrastructure, entitlements, & master planning. Proven leader skilled in uniting cross-regional teams to drive financial, operational, & regulatory excellence from project inception to full occupancy.
William’s Expertise
Experience
With more than 30 years in commercial real estate and construction, and the last 25 years of progressive leadership in commercial real estate, William DePippo has built a reputation as one of the most trusted and capable executives in the industry. His career spans field operations, construction management, and full-cycle real estate development—culminating in his role as a Senior Vice President at the nation’s leading life science REIT, where he directly oversaw the planning, entitlement, and execution of more than $1.5 billion in high-performance assets since 2020.
Insider Knowledge
What sets William apart is the foundation of his career: he started in the field, performing hands-on labor on complex construction sites. From those early days, he developed an intuitive, working knowledge of how great buildings come together—gaining deep insight into cost, schedule, and operational alignment. This field-tested perspective shaped his approach as he transitioned into construction management roles, eventually leading large-scale project delivery for national firms, including a tenure at JLL, where he managed multi-sector developments across life sciences, biotech, mixed-use, and residential portfolios.
Leadership
Over the past 20 years, William has held leadership roles within a publicly traded company—sharpening his operational awareness, financial discipline, and alignment to reporting metrics. This experience has honed his ability to make value-based decisions under pressure, balancing speed and certainty with accountability, even when the stakes are high and impacts are inevitable.
Why Choose William
Throughout his career,
William has delivered over 11 million square feet of award-winning, LEED-certified projects across some of the country’s most complex real estate markets—including Cambridge, MA, the biotech corridors of North Carolina’s Research Triangle, and the growing life science clusters of Maryland. His portfolio includes flagship campuses for Fujifilm Diosynth, Beam Therapeutics, MilliporeSigma, and the nationally recognized ACLS-Shady Grove project, among many others.
In Cambridge alone,
William played a key role in the development and repositioning of over 1 million square feet, including 399 Binney Street, 50 Rogers Street, 11 Hurley Street, and IBM’s headquarters at 75/125 Binney. His leadership extended from entitlement through construction and disposition, managing rezoning strategies, navigating infrastructure and land use constraints, and overseeing successful sales to major institutional investors.
A cornerstone of William’s philosophy
is jobsite safety and clean, coordinated delivery. Influenced by his early work in the trades, he champions environments that prioritize safety, respect, and quality—ensuring every team member goes home safe and every project stands the test of time. His teams consistently exceed expectations through a clear focus on risk mitigation, value creation, and project integrity.
William is known as
the person brought in when the stakes are high—when timing, execution, and stakeholder alignment are non-negotiable. He brings vision, discipline, and unmatched operational fluency to every phase of development, from initial feasibility and utility planning to tenant improvements and final turnover. His strategic mindset, coupled with a hands-on leadership style, has helped transform underutilized assets into dynamic, revenue-generating campuses.
William DePippo’s career
is a testament to earned leadership—one built not in boardrooms alone, but from jobsite grit, cross-functional mastery, and consistent delivery in some of real estate’s most challenging environments. He continues to set the standard for real estate professionals who know how to build, lead, and unlock lasting value.